Abstract
The aim of the research was to study formation of thymic lymphocytes proliferative response to T cell mitogen Concanavalin A in 7, 42, and 70 days-old male Wistar rats developmentally exposed to low doses of endocrine disruptor dichlorodiphenyltrichloroethane (2.90 ± 0.13 μg/kg body weight). The thymus of the exposed rats did not show morphological abnormalities. Exposure to the endocrine disrupter was found to alter age-dependent changes of thymic lymphocyte proliferative activity and attenuate proliferative response to Concanavalin A in puberty and adulthood. Insufficient response to mitogen was mediated by higher content of actively proliferating Ki-67-positive lymphoblasts compared to the control values. Insufficient proliferative response to mitogen in developmentally exposed to the endocrine disruptor rats may provide higher risk of impaired cellular immune reactions.
Highlights
Dichlorodiphenyltrichloroethane (DDT) is considered one of the most wide-spread persistent organic pollutant on the planet [1, 2]
At the age of 42nd days thymus mass was slightly increased compared to the control, but the difference was statistically insufficient (Table 1)
Our investigation of proliferative response to Concanavalin A during postnatal development found that it was well-developed in neonatal rats and reached maximal values in puberty
Summary
Dichlorodiphenyltrichloroethane (DDT) is considered one of the most wide-spread persistent organic pollutant on the planet [1, 2]. Pervasion of the environment by DDT and its metabolites is a result of massive use as a pesticide in the 20th century. DDT was banned in many developed countries, but in developing countries it is still used for disease vector control. Continued extensive use as insecticide for malaria control in Africa, Asia and Latin America and long half-life provide further worldwide contamination of environment by DDT and its metabolites [3]. The danger of low-dose exposure is associated with high lipophylicity and low molecular weight of DDT. DDT and its metabolites penetrate blood-tissue barriers and accumulate in different inner organs especially in adipose tissue [4]
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