Abstract
The aim of this study was to determine the effect of chronic corticosterone (CORT) administration on pre‐pubescent and post‐pubescent female rats in order to develop a rat model of depression in these age groups. Rats were administered daily injections of CORT (40 mg kg‐1) for twenty‐one days. Depressive‐like behavior was assessed using the modified forced swim test (FST) and the sucrose preference test (SPT). Immunohistochemistry was used to determine changes in mitogenesis and survival of newborn neurons in the dentate gyrus of the hippocampus. Chronic CORT treatment produced significant changes in the FST for post‐pubescent rats, but not pre‐pubescent rats. Conversely, CORT produced significant changes in the SPT for pre‐pubescent rats, but not post‐pubescent rats. Ongoing investigation will determine the effect of CORT on mitogenesis and survival of newborn neurons in the dentate gyrus of pre‐pubescent and post‐pubescent female rats. These results suggest that CORT may induce depressive‐like behavior in female pre‐pubescent and post‐pubescent rats; however, the physiological effect is manifested differently at different stages of rat development.Grant Funding Source: Supported by AT Still University of Health Sciences grant and the Warner‐Fermaturo Fund
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