Abstract
Study of the reproduction of animal viruses in conjunction with susceptible host cells is hampered by many technical problems which are not, or are less, apparent in analysis of bacteriophage replication. In most animal host-virus systems the susceptible cell constitutes an integral part of a complex organ or tissue, composed of a variety of cells not all of which are capable of supporting multiplication of a particular virus. Furthermore, infection of these tissues or organs frequently has to be studied within the intact animal. Thus, the quantitative aspects of infection cannot be readily evaluated in most host-virus systems, both the numbers of susceptible cells and of virus units entering cells as a rule being unknown. In addition, it is frequently impossible to differentiate between extra- and intra-cellular virus. Furthermore, the infectious process rarely can be restricted to one infectious cycle, covering the period from adsorption of a virus onto a...
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