Abstract
SUMMARYDNA, RNA and protein concentrations, cathepsin D activity and tritiated thymidine incorporation into DNA were measured in selected muscles from newborn to 7-day-old ‘splayleg’ piglets. The results indicated that the pattern of development differed considerably from that observed in muscle from normal piglets, and the range of results was greater both within and between affected animals. The most striking difference between muscle from normal and ‘splayleg’ piglets was in the incorporation of tritiated thymidine, which was lower in the latter from 3 to 6 days of age, indicating that the number of cells undergoing mitosis may have been reduced. It is suggested that this could have a severe effect on future muscle growth especially if satellite cells are affected.
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