Abstract
Tissue specificity and developmental changes in glycosaminoglycans were studied in chick embryo skeletal muscle cells differentiating in vitro. Myogenic cells appear to be able to synthesize three main kinds of glycosaminoglycans, namely hyaluronic acid, heparan sulfate and chondroitin sulfate. The patterns of glycosaminoglycans synthesized by terminally differentiated multinucleated myotubes are clearly distinguishable from those synthesized by duplicating mononucleated myogenic cells and by sparse or confluent fibroblasts. These multinucleated myotubes, in particular, exhibit a specific increase of heparan sulfate and a specific decrease of hyaluronic acid in their cell layer-associated fraction of the total synthesized glycosaminoglycans.
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