Abstract
During postnatal development, UDP-Gal:GlcNac(β1–4)-galactosyltransferase (4β-GT) and UDP-Gal:GalNAc(β1–3)-galactosyltransferase (3β-GT) activities were increased by 17- and 24-fold, respectively, in the rat small intestine. The injection of cortisone into suckling rats resulted in precocious induction of distal 4β- and 3β-GT activities by 2.7- and 18-fold, respectively. Injection of phorbol-12-myristate-13-acetate (PMA) resulted in precocious induction of distal 3β-GT by 2.7-fold. These results suggest that intestinal galactosyltransferase activities are under developmental regulation and can be modified by cortisone and PMA.
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