Developmental changes in continuity and stability of breathing in the fetal lamb.

Abstract

Developmental changes in the continuity and stability of fetal breathing patterns were studied in 27 fetal lambs with chronically implanted electromyographic electrodes in the diaphragm throughout the third trimester (102-140 days). The results showed that there was a progressive decrease in the incidence of fetal breathing movements throughout the third trimester (P less than 0.001). This reduction in incidence of fetal breathing movements was due, in part, to a 20% decrease in the total number of breathing bursts at approximately 125 days (P = 0.05). The breathing patterns in both immature (less than 120 days) and mature fetal lambs were fragmented by a large number of pauses (interburst interval 6-10 s) and apneas (interburst interval greater than 10 s). Increase in gestational age was associated with a decrease in the number of pauses and apneas but longer apnea durations. The breathing pattern in fetuses less than 120 days old was more continuous than that in those greater than 120 days old, as demonstrated by significantly longer epoch durations (P = 0.013). There was no significant change in the continuity of the breathing pattern after 120 days. However, there was a significant increase in the stability of the instantaneous breathing rates throughout the third trimester. This was indicated by a significant increase in the percent of breathing bursts that occurred in stable clusters (P = 0.046), the number of bursts per cluster (P = 0.013), and cluster duration (P = 0.018). Thus an increase in stability appears to be the major developmental change in breathing control in late gestation.