Developmental Cell Biology in Adult Stem Cells Death and Autophagy to Trigger a Preventive Allergic Reaction to Common Airborne Allergens under Synchrotron Radiation Using Nanotechnology for Therapeutic Goals in Particular Allergy Shots (Immunotherapy)

Abstract

Tree Pollen, Grass Pollen, Weed Pollen, Mold Spores, Cat Dander, Dog Dander, House Dust Mites, Cockroaches, Feathers, other dander and organic fibers are most effective airborne allergens. Airborne allergens coordinate to DNA/RNA and this coordination not only inhibits replication and transcription of DNA/RNA, but also leads to programmed adult stem cells death and autophagy (apoptosis) to trigger a preventive allergic reaction to common airborne allergens under synchrotron radiation using nanotechnology for therapeutic goals in particular allergy shots (immunotherapy). The corresponding trans isomer of airborne allergens also forms a coordination complex with DNA/RNA, but unlike cis isomer, trans isomer is not an effective chemotherapeutic agents. This editorial was designed to compare the interactions of cis and trans isomers of airborne allergens with adult stem cells DNA/RNA in aqueous solution at physiological conditions by 1 HNMR, 13CNMR, 31PNMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR– FTIR), FT–Raman, UV–Vis and HR Mass spectroscopic methods using constant DNA/RNA concentration and various Nano drug/ DNA/RNA (Phosphate) ratios. 1 HNMR, 13CNMR, 31PNMR, Attenuated Total Reflectance Fourier Transform Infrared (ATR– FTIR), FT–Raman, UV–Vis and HR Mass spectroscopic methods have used to determine binding constant and the stability of DNA/ RNA in Nano drug–DNA/RNA complexes in aqueous solution. Spectroscopic evidence showed major binding of cis isomer to G–N7 DNA/RNA with overall binding constants.