Abstract
An analysis of fruit-fly embryos reveals that receptor proteins of the Toll family direct the oriented cell rearrangements required for the elongation of the head-to-tail axis during development. See Article p.523 Body elongation along the head-to-tail axis is essential during animal development. In Drosophila, the spatial cues for elongation are provided by the patterned expression of genes. How the spatial cues direct the cell rearrangements required for elongation has been unknown. This study identifies three cell-surface Toll family receptors, expressed in stripes along the head-to-tail axis, that modulate the contractile properties of cells to generate the polarized rearrangements leading to tissue elongation.
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