Abstract
We propose ultra-high resolution optical coherence tomography to study the morphological development of internal organs in medaka fish in the post-embryonic stages at micrometer resolution. Different stages of Japanese medaka were imaged after hatching in vivo with an axial resolution of 2.8 µm in tissue. Various morphological structures and organs identified in the OCT images were then compared with the histology. Due to the medaka's close resemblance to vertebrates, including humans, these morphological features play an important role in morphogenesis and can be used to study diseases that also occur in humans.
Highlights
Medaka, Oryzias lapties is a small fresh water fish inhibiting the rice fields and ponds throughout Japan
Comparison of Fig. 3(A) with Figs. 3(B), 3(C) and 3(D) shows that the same features can be identified from the Optical coherence tomography (OCT) images
The boundaries of the brain regions are visible in the OCT image, which are generally associated with proliferation zones and are considered as an important element in neurogenesis [34,35]
Summary
Due to its close resemblance to vertebrates in genetics and organogenesis, the medaka has been used in various studies on diseases that occur in humans. Their short generation time of 2-3 months and the transparency of its eggs make it easy to follow their early development and they are grown in a laboratory environment. Most of the studies follow the growth of different organs of the medaka in the embryo [2]. Morphological features of internal organs in medaka post hatching that have been reported earlier are presented below
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