Abstract
Recent application of flow cytometric immunophenotyping to childhood disease states has highlighted the need for reliable lymphocyte data ranges in normal infants and children. In the management of pediatric human immunodeficiency virus (HIV) disease and in the diagnosis of DiGeorge syndrome, T-cell enumeration plays a vital role and extrapolation from adult normal range data has been misleading. Here, the findings of a multicenter study of 110 normal pediatric subjects divided into cohorts of newborns, infants (ages 2 days to 11 months) and children (1 to 6 years and 7 to 17 years) are presented. These age divisions were chosen to reflect maturational events in the immune system, such as antigenic challenges and vaccination. Pediatric results were compared to those of 101 normal adults evaluated at the same centers using the same methods.
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