Year-end Sale % OFF 
Abstract
Developmental alterations in N- methyl- d-aspartate (NMDA)-stimulated [ 3H]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10–1000 μM) resulted in a concentration-dependent increase in [ 3H]norepinephrine efflux; maximal responses (% released) in the cortex were: (1.53 ± 0.12, 3.68 ± 0.20, 2.94 ± 0.20, 4.60 ± 0.28 and 5.28 ± 0.33) and the hippocampal responses were: (1.90 ± 0.18, 3.84 ± 0.23, 3.60 ± 0.28, 5.16 ± 0.38 and 5.81 ± 0.45) at varying postnatal ages (1, 7, 14, 21 and 90 days) respectively. Cortical tissue from 7-day-old pups exhibited a transient increase in maximal efflux and a decrease in EC 50. These results indicated that developmental alterations in the NMDA receptor appear to be translated into differences in NMDA stimulated [ 3H]norepinephrine release.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
