Abstract
Objectives: It is suggested that there is a possibility to improve the quality and the developmental ability of oocytes from old patients by microinjection of intact ooplasm of young donors (Mol Hum Reprod, 1998;4:269–280). Whole exchange of cytoplasm between patient and donor oocytes can be completed by using the pronuclear (PN) transfer technology, and this may maximize the improving of oocytes quality. This study was conducted to know the safety of the PN transfer technology using mice oocytes as an animal model.
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