Abstract
Background: In vitro-in vivo correlation (IVIVC) is a quantitative and reliable relationship between in vitro drug release and in vivo absorption, which is desirable for rational development and optimization of sustained release formulations. The present work demonstrates development and application of IVIVC for 150 mg sustained release tablets of bupropion hydrochloride. Keywords: Bupropion, sustained release, dissolution, deconvolution, IVIVC, validation.
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