Development strategy of the registry of donors of hematopoietic stem cells

M A Loginova,I V Paramonov

doi:10.21682/2311-1267-2020-7-4-35-42

Abstract

Aim of the study— to develop a strategy for the recruiting potential donors to the registry, which is based on the biological characteristics of russian populations.Materials and methods. The object of the study was 35,117 potential donors of the hematopoietic stem cells of the registry of KRIHBT FMBA of Russia, recruited in 22 subjects of the Russian Federation.Results. Based on a comparison of the HLA-A-B-C-DRB1 haplotype profiles of local donor populations, calculated using the EM-algorithm in the Arlequin v.3.5.2.2 software, with the profile of the pooled donor population of the registry, general requirements for the recruitment of potential hematopoietic stem cells donors to the registry were formulated.

Highlights

Aim of the study – to develop a strategy for the recruiting potential donors to the registry, which is based on the biological characteristics of russian populations
[Boldyreva M.N., Guskova I.A., Bogatova O.V., Yankevich T.E., Khromova N.A., Tegako O.V., Ashramentova L.A., Ischuk M.V., Dubova N A.A., Ganicheva L.L., Pozdeeva O.S., Balanovskaya E.V., Alekseev L.P. HLA-genetic diversity of the population of Russia and the CIS

Summary

Development strategy of the registry of donors of hematopoietic stem cells

Aim of the study – to develop a strategy for the recruiting potential donors to the registry, which is based on the biological characteristics of russian populations. The object of the study was 35,117 potential donors of the hematopoietic stem cells of the registry of KRIHBT FMBA of Russia, recruited in 22 subjects of the Russian Federation. Поиск Для определения частот встречаемости HLA-гадонора ГСК за рубежом в 3–4 раза дороже, чем внутри плотипов методом максимального правдоподобия страны. Что при населении 146,5 млн, потенциальных доноров ГСК мы руководствовались включающем более 180 народов и национально- необходимостью максимального охвата регионов РФ, стей [10], рекрутинг новых потенциальных доноров граничащих или расположенных в удобной логисти-. Это увели- ления [13, 14], отличающие их от других российских чивает частоту встречаемости новых HLA-гаплотипов популяций – Республики Башкортостан и Чувашия.

Кировская область Kirov Region

Татарстан Republic of Tatarstan

Удмуртская Республика Udmurtia

Стандартное отклонение Standard deviation

Republic and pooled donor population of the registry