Abstract
A robust process for the radiosynthesis of 3/5-[18F]fluoropyridines has been developed by radiofluorination of iodonium triflates using K18F/K2CO3/K222 complex in the presence of TEMPO. Both electronically deficient and enriched iodonium salts were readily obtained from the corresponding 3/5-iodopyridines and afforded the corresponding 3/5-[18F]fluoropyridines in 6–78% yields. The concentrations of K2CO3 and TEMPO were found to be crucial for the radiofluorination efficiency. The process was validated using two automated systems for the 18F-radiolabeling of 2-chloro and 2-carboxamido-5-fluoropyridines carried out in 10–20% yields.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
