Abstract
BackgroundPresent investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio of matrix polymers (hydrophilic and hydrophobic), the concentration of plasticizer and natural penetration enhancer by Box–Behnken statistical design to investigate the combined outcome of selected independent variables for effective management of rheumatoid arthritis.The influence of a binary mixture of polymers, plasticizer and penetration enhancer on physicochemical considerations including thickness, tensile strength, percent elongation, weight variation, percent moisture content, percent moisture uptake, water vapour transmission rate, folding endurance, drug content, in vitro drug dissolution study and then ex vivo drug permeation study was evaluated.ResultsThe study demonstrated that the tensile strength of films improved by matrix polymer ratio and to a slighter gradation in the rise of plasticizer and natural penetration enhancer. Ex vivo drug permeation study was accompanied via excised porcine skin as a permeation barrier in Franz diffusion cell. Ex vivo drug permeation study indicated that matrix polymer ratio (HPMC K15M:ERL100) at 3:1 and natural penetration enhancer (d-limonene) at highest concentration 7.5% w/w containing formulation FBPT7 delivered maximum flux and supplementary improved the permeation of drug. The result of the skin irritation test revealed that the developed formulation is free from any type of skin irritation effects like erythema and oedema.ConclusionBased on the findings of this research, it can be established that a well-controlled release and very effective skin penetration of the drug was accomplished by the film FBPT7 in the existence of permeation enhancers for prolonged periods.
Highlights
Present investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio of matrix polymers, the concentration of plasticizer and natural penetration enhancer by Box–Behnken statistical design to investigate the combined outcome of selected independent variables for effective management of rheumatoid arthritis
The Fourier transform infrared spectroscopy (FT-IR) spectra of the ternary combinations FBP:HPMC Hydroxy propyl methyl cellulose (K15M):Eudragit RL 100 (ERL100) exhibited that the chief peaks of FBP were retained and detected at wavenumbers 3369.64, 1696.06 and 1128.25 cm−1
Differential scanning calorimetry (DSC) study DSC investigation of FBP, HPMC K15M, ERL100 and their physical mixture is presented in the figure
Summary
Present investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio of matrix polymers (hydrophilic and hydrophobic), the concentration of plasticizer and natural penetration enhancer by Box–Behnken statistical design to investigate the combined outcome of selected independent variables for effective management of rheumatoid arthritis. Joshi and Garud Future Journal of Pharmaceutical Sciences (2021) 7:57 limitations of the oral conventional drug delivery system like tablets, capsules, etc. This is more dangerous to drugs whose toxic and therapeutic drug levels are close or have a narrow therapeutic range. Concerning the form of the molecule, it requires to be carried through the skin, and this layer is very selective; only molecules with unique physicochemical properties can sufficiently travel through the skin [3] This leads to the variety of available transdermal drugs that can be delivered to be very limited, which demonstrates the need to integrate penetration enhancers into formulations that could help distribute a broader range of drugs efficiently [4]. Several cyclic terpenes like cineole, d-limonene and α-pinene have been intensively investigated as penetration enhancers
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