Development of Zinc-Doped Hydroxyapatite by Sol-Gel Method for Medical Applications.

Catalin Negrila,Daniela Predoi,Simona Iconaru,Mihai Predoi

doi:10.3390/molecules23112986

Abstract

Zinc- (Zn) doped hydroxyapatite (HAp) were prepared by sol-gel method. Zinc-doped hydroxyapatite (ZnHAp) and HAp were analyzed by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The Rietveld analysis revealed that the HAp and 7ZnHAp powders obtained by sol-gel method have a monophasic hydroxyapatite structure belonging to the P63/m spatial group. The results obtained from the ultrasound characterization of HAp and ZnHAp are also presented in this study. The effect of zinc concentration on properties that were deduced from ultrasonic measurements are studied in the case of a significant zinc concentration (xZn = 0.07). From the values of the ultrasonic waves velocities were determined by the pairs of elastic coefficients of the suspensions (Young modulus E, Poisson coefficient ν), which have proven to be similar to those determined by other authors.

Highlights

The most famous biocompatible materials generally used as coatings for implantable devices is hydroxyapatite (HAp)
The results obtained from the ultrasound characterization of HAp and Zinc-doped hydroxyapatite (ZnHAp) are presented in this study
The X-ray diffraction (XRD) analysis of HAp and 7ZnHAp samples using the Rietveld refinement method revealed a single phase corresponding to the hexagonal hydroxyapatite

Summary

Introduction

The most famous biocompatible materials generally used as coatings for implantable devices is hydroxyapatite (HAp). Due to its outstanding biological and physico-chemical properties, HAp, is widely used in biomedical applications for hard tissue replacements, scaffolds, as coating for implantable devices, and as a reinforcement material in biocomposites [3,4,5,6]. Some drawbacks of HAp such as slow growth rate and the predilection of facilitating bacterial adherence and proliferation have been identified [7]. Due to their biodegradability, good biocompatibility, and great mechanical properties, various metals such as iron, zinc, magnesium, calcium, manganese, sodium, potassium, etc. Zinc has attracted considerable attention recently, because it exhibits great biocompatibility [13], osteoconductive properties [14], and has been reported to have a direct effect on the in vitro bone mineralization [15,16]

Objectives

Methods

Results

Conclusion