Abstract
Autologous platelet-rich fibrin (PRF) is derived from the blood and its use in the bone tissue engineering has emerged as an effective strategy for novel drug and growth factor delivery systems. Studies have approved that combined therapy with PRF ensures higher biological outcomes, but patients still undergo additional treatment with antibiotic drugs before, during, and even after the implantation of biomaterials with PRF. These systematically used drugs spread throughout the blood and lead not only to positive effects but may also induce adverse side effects on healthy tissues. Vancomycin hydrochloride (VANKA) is used to treat severe Staphylococcal infections but its absorption in the target tissue after oral administration is low; therefore, in this study, we have developed and analyzed two kinds of VANKA carriers—liposomes and microparticles in 3D PRF matrices. The adjustment, characterization, and analysis of VANKA carriers in 3D PRF scaffolds is carried out in terms of encapsulation efficiency, drug release kinetics and antibacterial activity; furthermore, we have studied the micro- and macrostructure of the scaffolds with microtomography.
Highlights
IntroductionThe use of platelet-rich fibrin (PRF) in tissue engineering has emerged as an effective strategy for novel drug delivery systems [1]
Introduction published maps and institutional affilThe use of platelet-rich fibrin (PRF) in tissue engineering has emerged as an effective strategy for novel drug delivery systems [1]
In order to develop a controlled VANKA delivery system based on PRF, VANKA
Summary
The use of platelet-rich fibrin (PRF) in tissue engineering has emerged as an effective strategy for novel drug delivery systems [1]. The use of autologous PRF can improve the biological outcomes of the bone and tissue regeneration procedures, especially in maxillofacial surgeries [4,5,6]. Used drugs, without a specific carrier, spread throughout the body and often drug degradation rate is relatively short. It ensures a positive effect on the damaged tissue, but may induce adverse side effects on healthy tissues [11].
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