Development of trisubstituted thiophene-3-arboxamide selenide derivatives as novel EGFR kinase inhibitors with cytotoxic activity

Abstract

Selenides of substituted thiophene-3-carboxamide derivatives are designed and synthesized to explore their antiproliferative potential with EGFR inhibition. The excellent in vitro results present a novel hit molecule with EGFR kinase inhibition (nM).