Abstract
Determination of antidiabetic compounds from Helicteres isora fruits by oral glucose tolerance testGovindasami Chandirasegaran, Chakkaravarthy Elanchezhiyan, Kavisa Ghosh, Subramaniyan Sethupathy
Highlights
Several drugs such as berberine chloride derived from natural ingredients are Mohsen currently being developed
The Berberine chloride (BBR) transfersomes were formulated into emulgel and in vitro penetration was carriexd out using Franz diffusion cells for 12 hours
The transfersomes pass through the intercellular route, they were elastic to pass through the stratum corneum pores which were much smaller than their size
Summary
Several drugs such as berberine chloride derived from natural ingredients are Mohsen currently being developed. Berberine chloride (BBR) is a natural isoquinoline alkaloid isolated from medicinal herbs such as Coptis chinensis, Coptis japonica Makino, Berberis aristate, Berberis vulgaris, and Rhizoma coptidis. BBR has low permeability due to the presence of methoxy and ammonium quartener groups in its structure, as shown in Figure 1 (Li et al, 2017; Narade and Pore, 2019). This is in line with a study by Torky et al (2018), which showed that the permeation ability of BBR gel into the skin was restricted and many drugs stayed on the skin surface
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