Abstract
Selegiline transdermal drug delivery system (TDDS) of drug-in-adhesive matrix type was developed using acrylic-rubber hybrid pressure sensitive adhesive (PSA). The permeation rate of selegiline was the highest from silicone, followed by acrylic-rubber hybrid, acrylics. Although the permeation rate of silicone PSA was higher than that of acrylic-rubber hybrid PSA, the cold flow of silicone PSA was unacceptable. When the drug concentration was increased from 3.5 to 8 % w/w of polymer weight, the drug permeation rate also increased proportionally. The correlation coefficient (R2) between selegiline content in the TDDS and the average cumulative amount permeated was 0.999. When the stability study of the TDDS was carried out at the accelerated condition of 40 °C/75 % relative humidity for 12 weeks, no significant changes in both the physical appearance and the drug content were observed. The drug permeation rate from the TDDS was much higher than that from Emsam®. The average cumulative flux of selegiline from the TDDS was 2 times higher than that from Emsam®.
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