Development of Topical Diclofenac Sodium Liposomal Gel for Better Antiinflammatory Activity

Abstract

The objective of this study was to develop a diclofenac liposomal gel intended for better anti-inflammatory activity compared to a normal gel after topical administration. Spherical multilamellar vesicular liposomes (MLVs) consisting of soya lecithin, cholesterol and diclofenac were prepared via thin film hydration methodology. Small unilamellar vesicles (SUVs) were then prepared out of MLVs. Entrapment efficiency, the drug associated with SUVs was subsequently determined. Liposomal gel formulations were then prepared by incorporation of SUVs into carbopol 934 gel previously prepared. The formulations were then characterized for in vitro drug release, ex vivo permeation studies, drug-lipid compatibility and rheological behaviour. Vesicle size/Zeta potential of the liposomes containing in one selected formulation were determined. Pharmacodynamics was also determined for selected diclofenac liposomal gel. Diclofenac liposomal gel formulation prepared showed more sustained and prolonged anti-inflammatory effect compared with diclofenac gel. Taken together, the results indicate that the diclofenac liposomal gel is better than the regular gel without liposomes. Drug-lipid compatibility studies indicated no interaction with drug and the polymer.