Abstract
Theophylline 25 mg/kg i.p. produced long-lasting contralateral rotation in mice with unilateral striatal 6-hydroxydopamine lesions, while repeated administration of theophylline caused a prominent reduction in the rotation. When mice received theophylline in combination with L-dopa, no reduction in the response was observed. Determination of forebrain theophylline showed no significant metabolic changes. These results suggest that a functional tolerance develops to the stimulating effect of theophylline on the nigrostriatal dopaminergic system.
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