Development of the Technology of Polymer Films Containing Immobilized Protease and Dioxidine

Abstract

A water-soluble polymeric film (Prodioxilong pellicles) containing the proteolytic enzyme procelan and the broad-spectrum antimicrobial drug dioxidine has been created. This medicinal form ensures full bioaccessibility and exact dosage of the drugs, retains activity for a prolonged time, and is convenient to use for the treatment of deep suppurative necrotized wounds and purulent inoculations, in particular, in stomatology. Based on the results of biological evaluation of the duration of action and physicochemical properties of the new preparation, the shape and dimensions of the pellicles were selected, the composition and technology were optimized, and the performance characteristics were established. The pellicles were characterized by the appearance, dimensions, pH of the pellicle suspension, the size of procelan and dioxidine particles, the weight loss on drying, the average weight, proteolytic activity, dioxidine content, and the level of microbiological contamination. The polymeric pellicles are stable for twelve months when stored under normal conditions.