Abstract
The hemoglobin pattern of embryonic and adult mice (strains C3H and C57 and the F 1 hybrids) was determined (both in vivo and after in vitro cultivation of hematopoietic organs) by a modified method of acrylamide gel electrophoresis. In the embryos of all the mice studied, the same four hemoglobin bands were observed until day 13 of gestation, when adult hemoglobins began to appear. The alteration to the adult pattern was completed by day 17. All the adult animals had two hemoglobin bands in common; strain C3H and the hybrids, (C3H × C57) F 1 and (C57 × C3H) F 1, shared one additional hemoglobin band not found in strain C57. The description of a cell type which may be an early precursor of hematopoietic cells was given. Only the embryonic type of hemoglobin appeared after electrophoresis of yolk sac (cultured in vitro), and only the adult type of hemoglobin was found in liver ( in vivo or cultured in vitro). It was suggested that the environment at the site of hematopoiesis determines the type of hemoglobin produced.
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