Development of the cream composition with Georgian thermal water and herb extracts

Abstract

Thermal mineral waters contain a certain amount of mineral substances. They are widely used around the world to develop pharmaceuticals and cosmetics. Georgia is rich in thermal mineral water and plant resources, but Georgian mineral waters and medicinal plant raw materials have not been used together in any of the dermato-cosmetic products produced in Georgia. The aim of this work is to develop the cream composition with mineral waters from Georgian hot springs and herb extracts. Material and methods. The objects of the study were Georgian thermal waters and herb extracts. Thermal waters of various degrees of mineralization were used: Sulori (mineralization - 182,6 mg/L), Tskaltubo (mineralization - 0,8 g/L) and Borjomi (mineralization - 5-7 g/L). For the study, the main methods for developing dosage forms, experimental and technological studies, physical, physico-chemical, biopharmaceutical and other methods were used. Research results. Based on preliminary tests, preference was given to highly mineralized water “Borjomi” and its dilutions. This allowed us to develop a general strategy for creating a formula for creams containing thermal mineral water and herb extracts. The experiments were conducted with different dilutions of Borjomi. A model system suitable for mineral waters of any degree of mineralization was developed. Preliminary tests determined the ratio of the main components, with the use of which ten versions of cream were developed, and their physicochemical properties, sterility and toxicological safety were studied. Conclusions. The critical analysis of thermal waters of Georgia was carried out and the more mineralized thermal water of Borjomi was used in the model systems. A methodological approach to the development of this type of medical and cosmetic creams for the use of selected thermal waters and plant raw materials was substantiated. The cream formulation was developed using Georgian thermal water and plant extracts. The conditions of their stability and safety were studied