Abstract
Chiral alcohols are an important class of compounds and possess a broad array of applications, thus their asymmet- ric preparation is an important area of research in the field of organic synthesis. Amongst methodologies for the preparation of such compounds, catalytic asymmetric hydrogenation has gained widespread interest due to its efficiency, environmentally friendliness and economic advantages, and is gradually becoming a technology with great potential for the industrial prepara- tion of chiral alcohols. This review provides the first overview for the catalytic asymmetric hydrogenation of enol esters for the synthesis of chiral alcohols. A comprehensive and up-to-date introduction are given for a number of different substrates. A thorough analysis is provided concerning the advantages and disadvantages of different chiral ligands and their transition-metal complexes. Finally, a brief discussion relating to developments and potential areas of further research concerning new sub- strates, new ligands and new catalytic metals, is presented. Keywords enol esters; chiral alcohols; asymmetric hydrogenation; Ru-catalyzed; Rh-catalyzed
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