Abstract
In order to develop a practical method for the construction of chiral molecules, we have designed a novel chiral system possessing two metal centers utilizing tartaric acid esters : that is, if two reactants are bound to the two metal centers of a dialkoxide derived from tartaric acid ester, they might be ideally oriented and/or activated by the metals and the subsequent reaction can proceed in an enantioselective manner to afford the corresponding optically active products. According to this working hypothesis, we could develop an asymmetric Simmons-Smith reaction, asymmetric 1, 3-dipolar cycloaddition reactions of nitrile oxides and nitrones, and an asymmetric nucleophilic addition reaction of dialkylzincs to nitrones.
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