Abstract
Cell membranes of early and late passage human embryo fibroblasts were freeze-fractured and the distribution of intramembrane particles was compared using statistical methods. Aged cells do not exhibit dramatic differences in total numbers of intramembrane particles when compared to younger cells. However, significant alterations develop with age between the distribution of particles on P and E fracture faces. Younger cells exhibit more particles on their P faces than corresponding membrane halves from older cells. In contrast, the E fracture faces of aged cells have significantly more particles than do corresponding surfaces of younger cell membranes. The observations suggest that properties of membrane fluidity may change with increased cellular age.
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