Abstract
AbstractA simple model of colony growth and product accumulation in an agar disc was developed assuming constant rate of increase of colony biomass and a maturation‐ decay behaviour of the specific productivity of the biomass. Experimental data obtained with three erythromycin‐producing strains of Streptomyces erythreus followed the predicted behaviour of the apparent specific productivity of the colony. The latter parameter exhibited a good correlation with the specific rate of product formation observed in liquid culture. A more sensitive correlation, and higher specific productivities, were obtained with agar discs made of a fermentation‐type medium than with a maintenance‐type medium. Estimation of the colony biomass through its surface area proved to be satisfactory in the conditions adopted, though it represents a major potential source of error.
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