Abstract
Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory and experimentally using dynamic light-scattering (DLS) and transmission electron microscopy (TEM) methods, the interaction of like-charged silica nanoparticles and detonation nanodiamonds in an aqueous solution was studied and their ratios selected for the formation of submicron-sized colloidosomes. The resulting colloidosomes were modified with additional layers of nanoparticles and polyelectrolytes, applying LbL technology. As a model anti-cancer drug, thymoquinone was loaded into the developed capsules, demonstrating a significant delay of the release as a result of colloidosome surface modification. Fluorescence flow cytometry and confocal laser scanning microscopy showed efficient internalization of the capsules by MCF7 cancer cells. The obtained results demonstrated a high potential for nanomedicine application in the field of the drug-delivery system development.
Highlights
Introduction published maps and institutional affilOne of the promising drug-delivery vehicles is microcapsule colloidosomes based on emulsions stabilized by solid colloidal particles—Pickering emulsions [1–3]
We studied the formation of submicrocolloidosomes with shells consisting of a mixture of charged detonation nanodiamonds (DNDs) and Ludox Cl nanoparticles
We studied the possibility of colloidosome stabilization using a mixture of LCl and nanoparticles in an aqueous medium, where they are charged
Summary
One of the promising drug-delivery vehicles is microcapsule colloidosomes based on emulsions stabilized by solid colloidal particles—Pickering emulsions [1–3]. The use of nanoparticles of various natures (organic, inorganic) and functionalities (magnetic [4,5], plasmon-resonant [6], fluorescent [7], etc.) allows the design of complex systems for theranostics. The structure and permeability of the nanoporous shells of such colloidosomes can be regulated by nanoparticle size, shape, surface properties [8–10], and additional layers (e.g., polyelectrolyte layers [11]), allowing control of the release of encapsulated substances. Colloidosomes based on oil-in-water emulsions can be used to deliver hydrophobic drugs [12], which cannot be independently transported in the bloodstream. The high stability and low toxicity of capsules based on Pickering emulsions make them preferable for systems derived from surfactant-based emulsions [1]. The high thermodynamic stability of the colloidosomes is provided by a decrease in total free energy since, under the condition iations
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