Development of spiral wave in a regular network of excitatory neurons due to stochastic poisoning of ion channels

Abstract

Some experimental evidences show that spiral wave could be observed in the cortex of brain, and the propagation of this spiral wave plays an important role in signal communication as a pacemaker. The profile of spiral wave generated in a numerical way is often perfect while the observed profile in experiments is not perfect and smooth. In this paper, formation and development of spiral wave in a regular network of Morris–Lecar neurons, which neurons are placed on nodes uniformly in a two-dimensional array and each node is coupled with nearest-neighbor type, are investigated by considering the effect of stochastic ion channels poisoning and channel noise. The formation and selection of spiral wave could be detected as follows. (1) External forcing currents with diversity are imposed on neurons in the network of excitatory neurons with nearest-neighbor connection, a target-like wave emerges and its potential mechanism is discussed; (2) artificial defects and local poisoned area are selected in the network to induce new wave to interact with the target wave; (3) spiral wave can be induced to occupy the network when the target wave is blocked by the artificial defects or poisoned area with regular border lines; (4) the stochastic poisoning effect is introduced by randomly modifying the border lines (areas) of specific regions in the network. It is found that spiral wave can be also developed to occupy the network under appropriate poisoning ratio. The process of growth for the poisoned area of ion channels poisoning is measured, the effect of channels noise is also investigated. It is confirmed that perfect spiral wave emerges in the network under gradient poisoning even if the channel noise is considered.