Abstract
Development of spinal cord neurons in delicate balance.
Highlights
The inner cell mass of the early embryo, or blastocyst, is composed of a population of undifferentiated cells that will eventually give rise to all the tissues of the adult animal
Observations made in developing mouse and chicken embryos have shown that spinal cord neurons differentiate from a population of progenitor cells, neuromesodermal precursors (NMPs), located in the posterior of the developing embryo
It is known that in vitro monolayer cultures of mouse embryonic stem cells (mESCs) secrete a protein called fibroblast growth factor (Fgf) that prompts their differentiation into neural progenitor cells, a type of stem cell that is able to produce cells of the neuronal lineage
Summary
The inner cell mass of the early embryo, or blastocyst, is composed of a population of undifferentiated cells that will eventually give rise to all the tissues of the adult animal. Observations made in developing mouse and chicken embryos have shown that spinal cord neurons differentiate from a population of progenitor cells, neuromesodermal precursors (NMPs), located in the posterior of the developing embryo.
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