Abstract
Malaria still remains one of the challenging public health issue infecting about 300-500 millions of people. The most serious and fatal malarial infections are caused by Plasmodium falciparum which has developed resistance to commonly employed therapeutics. Hence the need to develop a novel anti-malarial drug targeting Dihydroorotate dehydrogenase (DHODH), an enzyme involved in parasite growth. DHODH is present in both humans and Plasmodium falciparum. Sequence analysis and structure comparison of DHODH of both Human and Plasmodium falciparum reveals variations among them, thereby providing a chance to design a specific inhibitor. Virtual screening of existing anti-malarial drugs acting on DHODH is performed from Pubchem and BindingDB databases. Pharmacophore mapping was done for the top 20 virtual screening compounds using hip hop algorithm. The compounds thus obtained from screening, are docked with both Human and Plasmodium DHODH. Potential anti-malarial lead compounds can be developed to treat resistant strains of Plasmodium falciparum.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Computational Biology and Drug Design
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
