Development of sarcomas in Marshalbino mice following injection of desoxycorticosterone acetate in sesame oil.

Abstract

SummaryTwenty-four mice of the Marsh-Albino strain were injected daily for a period of 3 months with desoxycorticosterone acetate (0.2 mg/0.1 cc) in sesame oil. Of these, 1 was killed 3 months after termination of treatment but showed no evidence of tumor, while 9 others, killed 6 months after termination of treatments had subcutaneous tumors of two histological types, fibrosarcoma and myosarcoma. The remaining 10 mice are still alive; all show gross evidence of tumor formation, which became evident 6 months after completion of treatment.