Abstract
presence of cAMP, Ca2+ spark frequency was much higher in KI than in WT saponin-permeabilized cardiomyocytes, whereas it was largely reversed by co-addition of CaM-Gly-Ser-His. Conclusions: In response to PKA phosphorylation, CaM binding affinity to the CPVT-associated mutant RyR2 was markedly decreased. Correction of the reduced binding affinity of CaM to the mutant RyR2 inhibits aberrant Ca2+ release.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
