Development of portable SPR sensor devices based on integrated periodic arrays of nanoholes

Abstract

Periodic arrays of nanoholes are being developed by several groups for integrated and portable real-time sensing based on surface plasmon resonance (SPR). Recent advances have allowed for nanohole sensitivity comparable to ATR SPR. Here, we will present our new advances in developing integrated and multiplexed SPR sensors using nanohole arrays. For the first time, we will present our dual-wavelength approaches that remove the need for a spectrometer, thus greatly reducing cost and size. We will also present our recent achievements in (1) in-hole sensing, demonstrating attomolar detection, and (2) flow-through sensing, where the detection time is greatly reduced due to the rapid diffusion inside the nanoholes themselves.