Abstract
In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25® by using the spray drying technique. The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR 13C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles’ size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by using biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.
Highlights
The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC)
The NMR 13C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL
We obtained innovative microparticles of PCL/poly(vinyl alcohol) (PVAL) and PCL/PVAL/ NT-25, using emulsification techniques followed by spray drying
Summary
Monteiro et al 576 ticularly when they are developed with biodegradable polymers, due to its safety and biocompatibility [1]-[5]. Their main advantages are drug protection, mucoadhesion, gastroresistance, and controlled drug release, reducing the dose and frequency of drug administration, obtaining the same therapeutic effect with reduced adverse local and systemic effects and toxicity [6] [7]. Polycaprolactone (PCL) is a biodegradable polymer widely used in the development of microparticles due to its high stability, and permeability, biocompatibility with various drugs, low toxicity and low degradation rate. Its glass transition temperature is around 75 ̊C and its melting temperature is around 150 ̊C [12]-[15]
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