Abstract
BackgroundBy coalescing nanotechnology with photochemistry and microbiology, a new type of photoactive antimicrobial agent based on zinc oxide nanoparticles incorporated into biomacromolecular lignin was formulated, which possesses a wide-spectrum antimicrobial activity, providing effects in the field of antimicrobial photodynamic therapy. MethodsThe biomacromolecule lignin was functionally modified with 2-[(E)-(2-hydroxy naphthalen-1-yl) diazenyl] benzoic acid by Steglich esterification, and loaded with zinc oxide nanoparticles. The products were characterized by UV-Visible, FTIR, and NMR spectroscopic techniques, and by SEM, TEM, and X-ray diffraction analysis (XRD). The photoresponsive behavior of the dye, functionally modified lignin-dye ester and its nanoparticle dispersed product was investigated. The photoinduced antibacterial and antifungal effects of zinc oxide nanoparticle encapsulated functionally modified lignin were explicated in detail. ResultsThe photostabilization property of the chromophoric system was found to be enhanced when attached to lignin, and was further improved by the encapsulation of photoactive zinc oxide nanoparticles. The detailed studies on the photoinduced antibacterial and antifungal property revealed that upon light irradiation the antibacterial and antifungal efficacies of the test system got magnified. ConclusionsIncorporation of photoactive zinc oxide nanoparticles into the functionalized macromolecular system could make important changes in their photoresponsive abilities such as enhanced light absorption behavior and photostabilization properties enriched with photoinduced antimicrobial efficacy, which rendered the functionally modified system a potential photoinduced antimicrobial agent. They may find use in various biomedical applications especially in antimicrobial photodynamic therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
