Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents

Abstract

The proposed study is development of oro-dispersible tablet containing meclizine hydrochloride solid dispersion (FMODDs) formulation with using natural superdisintegrant with direct compression. The superdisintegrants and its concentration shall be during the preparation of FMODDs with meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), Ac-Di-Sol, crosspovidone (CP), Spray dried lactose and microcrystalline cellulose (MCC)} which were used alone and in various combination and mannitol, along with lubricant and glidants. The object of proposed work was preparation of FMODDs with a short disintegration time, sufficient mechanical strength, better patient compliance, and acceptable stability profile by employing different methods of preparation and studying different variables affecting pre and post-compression parameters of formulas of meclizine hydrochloride. The combination of agents have more disintegrating property due to rapid water uptake and dispersion time which lead to rapid release of drug and made the dissolution faster. The results of the release kinetics study showed that all the formulations obeyed first order drug release profile more closely, i.e., the release rate depended upon the initial concentration of drug.
 Keywords: Solid dispersion, Oro-dispersible, Fast disintegration, Direct compressed tablet, Meclizine hydrochloride, Superdisintegranting agents