Abstract
Multifunctional nanosystems combining magnetic and plasmonic properties are a promising approach for cancer therapy, allowing magnetic guidance and a local temperature increase. This capability can provide a triggered drug release and synergistic cytotoxic effect in cancer cells. In this work, nickel ferrite/gold nanoparticles were developed, including nickel ferrite magnetic nanoparticles decorated with plasmonic gold nanoparticles and core/shell nanostructures (with a nickel ferrite core and a gold shell). These nanoparticles were covered with a surfactant/lipid bilayer, originating liposome-like structures with diameters below 160 nm. The heating capacity of these systems, upon excitation with light above 600 nm wavelength, was assessed through the emission quenching of rhodamine B located in the lipid layer. The developed nanosystems show promising results for future applications in thermotherapy.
Highlights
Nanotechnology increasingly allows the development of new techniques and strategies for therapeutic applications, such as the use of hyperthermia [1,2]
Nickel ferrite nanoparticles were prepared by a co-precipitation route in a 5 mL aqueous solution, by reacting 1 mL of nickel chloride aqueous solution (1 M) and 2 mL of FeCl3 ·6H2 O solution (1 M)
Considering the main objective of this work, the development of magnetoliposomes on improved magnetic/plasmonic nanoparticles fori.e., applications in phototherapy, optimizationbased of theof the synthesis procedures the several components of the whole nanosystem was pursued
Summary
Nanotechnology increasingly allows the development of new techniques and strategies for therapeutic applications, such as the use of hyperthermia [1,2]. Gold nanoparticles were employed for local heating of cells, focusing on thermotherapy [4,5,6,7,8]. Owing to the large absorption cross-sections, plasmonic nanoparticles can produce significant heating and, can be used to increase local temperatures [8,9,10]. Plasmonic nanoparticles, mainly gold-based ones owing to their biocompatibility, found a wide range of applications in different technological areas, such as biosensors, clinical methods, immunology assays, photothermolysis of tumor cells, detection and control of microbial species, as vehicles for drugs, and in monitorization of cells [4,5,6,7,8,9,10]
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