Development of Novel Insect Growth Regulators: Effect of 1-(Substitutedbenzoyl)-3-[(2′-Isopropyl-5′-Methylphenoxy) Acetamino] Thiourea and Urea Derivatives on Total Haemocyte Count of Dysdercus koenigii

Abstract

Insect growth regulators (IGRs) are receiving more practical attention due to low mammalian toxicity and specificity in action. Benzoyl phenyl urea’s (BPUs) and N,N′- diacylhydrazines are the two prominent types of IGRs. Hence in present work these two important functional linkages have been assembled with a biologically active natural monoterpenoid, thymol, 2-isopropyl-5-methyl phenol, to generate two novel series of substituted benzoyl thiourea acetyl thymoxy hydrazine (BTATH) [IVa-f] and benzoyl urea acetyl thymoxy hydrazine (BUATH) [Va-f], with aim to generate more target specific molecules for control of different types of insects by keeping ecosystem undisturbed. The synthesized derivatives have been characterized by elemental analysis, IR, Mass spectroscopy, 1H & 13C NMR. All the Laboratory experiments were conducted to study the effect of the synthesized compounds on Total Haemocyte count (T.H.C.) of Dysdercus koenigii. T.H.C. in the treated insects increases up to 48 h and then declines upto 96 h. The series exhibited parallel pattern as that of Penfluron a standard IGR. The T.H.C. count is found to be dependent on number, position and type of substituent. Among all the derivatives 2,6-diF-BUATH compound caused a great reduction in haemocytes in both the sexes at 72 and 96 h after treatment.