Abstract
The central nervous system injury such as stroke can severely cause motor paralysis.Although the approach of rehabilitative training is developed, many patients still face restrictions in their daily living after rehabilitation. Thereby, a new compound with a strong potential to enhance motor function recovery with rehabilitation is an unmet medical need. We focus on the one of glutamate receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, which plays an important role in learning and memory. Here, we found a novel small low molecular compound, edonerpic maleate, that facilitated experience-dependent synaptic AMPA receptor delivery in the barrel cortex and dramatically accelerated motor function recovery after brain damage in a rodent model. Furthermore, edonerpic maleate enhanced the upper limb function recovery of macaque monkeys with internal capsule hemorrhage. Currently, a phase 2 clinical trial is being conducted to verify the efficacy of edonerpic maleate in stroke patients and has attracted global attention.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
