Development of novel Ce doped ZnO/graphene based sensor for electrochemical investigation of potassium-competitive acid blocker: Vonoprazan

Abstract

The present study reports the synthesis of a Ce-doped ZnO/r-GO nanocomposite via a conventional hydrothermal route. The synthesized nanocomposites were utilized for the purpose of sensitive and selective detection of vonoprazan (VPN). The composite’s morphological, structural, and electrochemical properties were thoroughly characterized. This study focuses on the utilization of a glassy carbon electrode that has been modified with Ce-doped ZnO/r-GO for the purpose of detecting the potassium-competitive acid blocker VPN, which is commonly used in the treatment of peptic ulcer. The detection methods employed in this study include voltammetric and square wave techniques. The composite material exhibited exceptional efficacy as an electron (e−) transfer mediator during the oxidation of VPN. The modified electrode exhibited a discernible reaction for SWV assessments in relation to VPN identification, achieving a minimal detection threshold of 1.8 × 10−8M and an extensive range of linearity spanning from 2.0 × 10−7 M to 8.0 × 10−6 M, given ideal circumstances. The rate constant for charge transfer (ks) was determined to be 1.17 × 10−6 cm s−1, and an estimation of the electrochemical active surface area yielded a value of 0.081 cm2. The sensor that was artificially created demonstrated favorable selectivity, enduring stability, and notable reproducibility. The sensor has been utilized for the purpose of analyzing human serum and urine samples, yielding favorable recovery outcomes.