Development of novel anti-inflammatory agents: a pharmacologic perspective on leukotrienes and their receptors.

Abstract

Inflammation is the body’s response to injury. Participation by a variety of cells and endogenous molecules make it a complex physiologic, and often times pathologic, event. Leukotrienes have been well documented to play a significant role, both as mediators of the acute inflammatory response and as contributors to the chronicity of the disorder. Research has concentrated in 3 main areas, understanding interactions of leukotrienes with complementary cell surface receptors, development of inhibitors of their synthesis, and discovery of receptor antagonists that block their pharmacologic effect. The following represents our view of this area with a bias toward medicinal chemistry, pharmacologic, and clinical studies related to our own research interests.KeywordsAdult Respiratory Distress SyndromeStyryl QuinolineCysteinylleukotriene ReceptorLTB4 ReceptorLTB4 Receptor AntagonistThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.