Abstract
Objective: Tuberculosis, known in short as TB, is considered to be a global crisis caused by Myco bacterium tuberculosis, and which continues to be a serious challenge to public health world wide especially in the developing countries. A serious problem related to tuberculosis is the development of drug resistant strains.
 Methods: Present study describes the synthesis of eight novel derivatives of 1,3,4-thiadiazole derivatives and in vitro evaluation of their anti tubercular activity against Mycobacterium tuberculosis H37 Rv strain by alamar blue assay. Pyrazinamide and Streptomycin were the standards, used for the evaluation.
 Results: Among the eight compounds synthesized one derivative was found to be active against the strain tested. All the other derivatives tested exhibited negligible activity against the strain.
 Conclusion: It can be concluded that novel 1, 3, 4-thiadiazole derivatives can be developed as novel agents in the fight against TB.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Current Pharmaceutical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
