Abstract
Nicotinic Acid (NA) is a cholesterol lowering agent used to treat dyslipidemia. Proanthocyanidins (PC) was selected as a drug and encapsulation material in which the later has a dual property of being a polymer as well as cholesterol lowering agent. The encapsulation of NA with different concentrations of (PC) was carried out by solvent evaporation technique. The encapsulated NA was converted to granules which were then compressed into tablets by wet granulation method. It was subjected to many pre-compression parameters evaluation such as flow properties, drug content and encapsulation efficiency. The tablets were evaluated for thickness, hardness, friability, <em>in vitro</em> release studies, release kinetics and stability studies. The evaluated parameters of the formulations showed compliance with pharmacopoeial standards. The encapsulation efficiency was 99.73% and 99.52% of drug content. The FT-IR spectrum did not show interaction between drug and polymer. The drug release in pH 1.2 was lesser than in pH 6.8 buffer. The encapsulated product released drug in controlled manner in alkaline medium. The drug release was 97.1% and release was extended up to 12 hrs. The optimized batch underwent stability studies as per ICH guidelines. It can be concluded that among all the formulations the F5 can be considered as optimized formulation. The optimized formulations showed non-fickian diffusion mechanism of release.
Highlights
There is an increase in the number of patients with chronic diseases off late., which necessitates taking drug for a longer time or multidrug together, which can lead to increase in non-compliance
One end of capillary tube was sealed and the fine powder of Nicotinic Acid (NA) was filled in the other end, which was tied to a thermometer placed in Thais tube and placed on fire
The melting point of NA was found to be in the range 236.4–236.6 °C which was compiled with BP standards, indicating purity of the drug sample
Summary
There is an increase in the number of patients with chronic diseases off late., which necessitates taking drug for a longer time or multidrug together, which can lead to increase in non-compliance. Oral controlled release systems continue to be the most popular among the drug delivery systems since it has many advantages over the conventional systems. It improves the patient compliance since it reduces frequent drug dosage, fluctuation of steady state plasma level thereby helping in better control of disease condition[1, 2]. PC is a condensed tannin consisting of oligomers and polymers of monomeric flavans They are present in several berries, red grapes and their wines, and seeds, baking chocolate, cinnamon, pycnogenol, and Ginkgo biloba[6, 7]. NA was chosen as a drug to develop a dissolution controlled system of NA by encapsulation with PC, a natural phenolic antioxidant polymer for the treatment of dyslipidemia
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
