Development of multiple cysts and of hemorrhagic afflictions of internal organs in albino rats treated during the embryonic or newborn period with Rous sarcoma virus.

Abstract

IN contrast to other malignant animal tumours, such as the Ehrlich adenocarcinoma of mice, the Croker mice sarcoma or the Brown–Pierce rabbit epithelioma, which could be transplanted to the embryos of white rats in serial passages1, the tissue of the Rous chick sarcoma could only exceptionally be grown under such conditions. However, in many rats grown from embryos inoculated with minced tissue of the Rous sarcoma we have detected2 multiple cysts. The observations recorded here reveal that white rats are highly susceptible to the Rous sarcoma virus administered both during embryonic life and the first two days of postnatal life.