Abstract
The aim of this study was to design and evaluate muco-adhesive orally disintegrating tablets manufactured by microwave irradiation and containing polysaccharide. We prepared orally disintegrating tea tablets (ODTTs) containing a 1 w/w% mass fraction of one of five polysaccharides (gum arabic, carrageenan, guar gum, tamarind gum, or pectin) and evaluated the swelling degree, tablet hardness, friability, disintegration time, and adhesive properties. All tablets had a swelling degree of about 1 mm, a hardness of over 13 N, and a friability degree of <1%. Tablets containing gum arabic and tamarind gum had disintegration times of 30 s or less and satisfied requirements as orally disintegrating tablets. This could be attributed to their high void contents, which allowed for water penetration. The adhesive properties and particle retention ratios were highest in ODTTs containing tamarind gum, which was thought to be caused by the rapid disintegration and high viscosity of the tamarind gum itself. When we investigated changing the mass fraction of tamarind gum, we found 1 w/w% was most suitable for rapid disintegration and high adhesiveness. The ODTTs containing 1 w/w% tamarind gum showed significant growth inhibition towards Streptococcus mutans. Therefore, microwave irradiation technology and addition of tamarind gum could be used to manufacture muco-adhesive orally disintegrating tablets for oral care.
Highlights
In the modern era, the pneumonia death rate has been increasing with population aging and super-aging societies (Miyashita and Yamauchi, 2018)
The adhesive properties and particle retention ratios were highest in the orally disintegrating tea tablets (ODTTs) containing tamarind gum, which could be attributed to the rapid disintegration and high viscosity of the tamarind gum itself
Among the mass fractions we studied, 1 w/w% tamarind gum is best for preparation of ODTTs
Summary
The pneumonia death rate has been increasing with population aging and super-aging societies (Miyashita and Yamauchi, 2018). Over 90% of pneumonia deaths are of older adults aged 65 years or older, and about 70% of older adults suffering from pneumonia have aspiration pneumonia (Teramoto et al, 2008; Baine et al, 2001). It is important to keep the oral cavities of older adults clean to prevent aspiration pneumonia. Effective oral care can prevent intraoral diseases (e.g., periodontal disease and dental caries) and systemic diseases such as angina, brain infarction, and diabetes that can be induced by intraoral disease. Oral care preparations can improve quality of life for older adults (Langmore et al, 1998; Teramoto et al, 2015), especially if the preparations are handled and can be taken even by bedridden patients
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